Defiance, MO ZIP code
The ZIP code for Defiance, Missouri is 63341. It is in St. Charles County.
- Population in these ZIPs
- 3,515
- Avg. median income
- $170,600population-weighted
- Typical home value
- $636,200population-weighted
- Metro area
- St. Louis, MO-IL
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Defiance, MO ZIP code list
| ZIP code | Population | Median income | Typical home value |
|---|---|---|---|
| 63341 | 3,515 | $170,598 | $636,200 |
Population and median household income: ACS 2020–2024 5-year estimates. Typical home value: Zillow Home Value Index (September 2026) where available, otherwise the ACS median owner-reported value. "PO Box" marks ZIP codes with no delivery area of their own. Methodology
Cities near Defiance
- New Melle 5 mi
- Saint Albans 6 mi
- Augusta 6 mi
- Lake Saint Louis 8 mi
- Labadie 9 mi
- Glencoe 9 mi
- Wentzville 10 mi
- O Fallon 11 mi
- Grover 11 mi
- Foristell 11 mi
- Chesterfield 12 mi
- Gray Summit 12 mi
Frequently asked questions
What is the ZIP code for Defiance, MO?
The ZIP code for Defiance, MO is 63341.
What county is Defiance, Missouri in?
Defiance ZIP codes are in St. Charles County.